Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.
Diphenhydramine and ibuprofen is a combination medicine used to treat occasional insomnia associated with minor aches and pains.
Diphenhydramine and ibuprofen is not for use in treating sleeplessness without pain, or sleep problems that occur often.
Diphenhydramine and ibuprofen may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Motrin PM (diphenhydramine and ibuprofen)?
Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).