Pramoxine Hydrochloride CAS 637-58-1
EINECS number: 211-293-1
Molecular formula: C17H28ClNO3
Molecular Weight: 329.8621
Boiling point: 427 ° C at 760 mmHg
Flash Point: 123.5 ° C
Vapor Pressure: 1.7E-07mmHg at 25 ° C
Appearance: White or almost white crystalline powder
Uses:Surgical anesthesia:Epidural anesthesia (including epidural anesthesia during cesarean section);Local infiltration anesthesia.
Acute pain control:For postoperative or labor analgesia continuous epidural infusion can be used can also be intermittent medication;Local infiltration anesthesia.
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride.
Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans.Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.
The popular itch creams Gold Bond and some forms of Calamine Lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.