Oral Safe and Super Pure 99% Vandetanib/ 4-Quinazolinamine/Zactima/ZD 6474
CAS 110958-19-5 for Cancer Treatment
Other Name: 4-Quinazolinamine;Zactima;ZD 6474
Purity : 99%
CAS : 443913-73-3
Appearance: Yellow Powder
Place of Origin: China
Brand Name: NJBNSteroid
Usage: Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM and is used as anticancer drug material.
Vandetanib is a kind of small molecule multi-targeted tyrosine kinase inhibitor studied and developed by the British AstraZeneca Company. In April 2011, it was approved the US FDA for entering into market under the trade name Zactima. The drug, as a tablet, can be applied to the treatment of advanced medullary thyroid cancer of adult patients.
A clinical trial conducted by doctors Ronald B. Natale from Los Angeles Cedars-Sinai Cancer Center, clinical study compared the treatment efficacy of vandetanib (300 mg/d) and gefitinib (250mg/d) on 168 cases of NSCLC patients who had been subject to failing first-line or second-line chemotherapy. Compared with gefitinib, vandetanib significantly increased efficiency and prolonged the progression-free survival, period respectively, by 8% and 1%, 11.9 weeks and 8.1 weeks, (P = 0.011).